This study sought to determine the technical adequacy of spirometry results, concordance between family physician and pulmonary expert interpretations of spirometry test results, and changes in asthma and chronic obstructive pulmonary disease (COPD) management following spirometry testing in primary care, using outcomes from 368 spirometry tests completed over a 6-month period. These tests involved 382 patients with asthma and COPD and staff from 12 family medicine practices across the US. A total of 71% of the tests were technically adequate for interpretation. Concordance between family physician and pulmonary expert interpretations of test results was observed in 76% of tests; concordance was higher for patients with asthma than for those with COPD. Changes in management occurred in 48% of patients following spirometry testing, including 107 medication changes (>85% concordant with guideline recommendations) and 102 nonpharmacological changes.