These researchers sought to determine the disease burden of diabetes in Canada. They estimated the lifetime risk of diabetes among men and women in both First Nations and non–First Nations populations using a cohort of adults residing in the province of Alberta from 1997 to 2008 who were free of diabetes at cohort entry. The analysis involved 70,631 First Nations and 2,732,214 non–First Nations people aged ≥18 years. Among First Nations people, women had a higher lifetime risk of diabetes than men across all index ages (87.3% vs 75.6%), whereas among non–First Nations people, men had a higher lifetime risk of diabetes than women across all index ages (55.6% vs 46.5%).