A qualitative study has revealed factors influencing antibiotic use and perceptions of antimicrobial resistance among Māori, as well as strategies for improving antibiotic use. In-depth, semi-structured interviews were conducted with 30 Māori aged 20-77 years enrolled in primary care, of whom 23% were male. Identified factors included general practitioner times and ratios, effect of colonisation, lack of knowledge and information, access and poverty barriers, relationship with health professionals, illness perceptions, treatment beliefs and Whaakaro (thoughts), and beliefs pertaining to natural (rongoā) and Western medicine. Potential strategies for improving antibiotic use included cultural support and involving Te Ao Māori