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Adherence, sexual behavior and sexually transmitted infections in a New Zealand prospective PrEP cohort

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Authors:
Summary:

Structural interventions and delivery innovations are needed to ensure ethnic minority gay and bisexual men gain equal benefit from pre-exposure prophylaxis (PrEP) against HIV, according to a study undertaken in Auckland. The study investigated the experiences of 150 gay and bisexual men (including 50% non-European) on PrEP over a 12-month period. Participant retention at 12 months was 85.9% (75.6% among Māori/Pacific and 90.1% among non-Māori/Pacific). Missed pills increased over time and were higher among Māori/Pacific participants. PrEP breaks also increased over time, by 12 months 35.7% of Māori/Pacific and 15.7% of non-Māori/Pacific participants had taken a PrEP break. The number of condomless receptive anal intercourse partners was stable over time. Sexually transmitted infections (STI) were common but chlamydia declined over the study period. The 12-month incidence of diagnosed infection was 8.7% for syphilis, 36.0% for gonorrhoea, 46.0% for chlamydia, 44.7% for rectal STI and 64.0% for any STI.

Comment:
My experience with the PrEP clinicians, and the work they do with South Auckland gay and bisexual community needing PrEP, has been very positive. The fact that they were able to recruit people into this study, and retain more than 75% of them for 12 months, speaks to the respect held for them by this community. I like that the recommendations focussed on structural and delivery interventions too.
Reference: AIDS Behav. 2022;26:2723-2737.
Independent commentary by Dr. Matire Hardwood

Dr Matire Harwood (Ngapuhi) has worked in Hauora Māori, primary health and rehabilitation settings as clinician and researcher since graduating from Auckland Medical School in 1994. She also holds positions on a number of boards, committees and advisory groups including the Health Research Council. Matire lives in Auckland with her whānau including partner Haunui and two young children Te Rangiura and Waimarie.

Research Review publications are intended for New Zealand health professionals.

Disclaimer: This publication is not intended as a replacement for regular medical education but to assist in the process. The reviews are a summarised interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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