Structural interventions and delivery innovations are needed to ensure ethnic minority gay and bisexual men gain equal benefit from pre-exposure prophylaxis (PrEP) against HIV, according to a study undertaken in Auckland. The study investigated the experiences of 150 gay and bisexual men (including 50% non-European) on PrEP over a 12-month period. Participant retention at 12 months was 85.9% (75.6% among Māori/Pacific and 90.1% among non-Māori/Pacific). Missed pills increased over time and were higher among Māori/Pacific participants. PrEP breaks also increased over time, by 12 months 35.7% of Māori/Pacific and 15.7% of non-Māori/Pacific participants had taken a PrEP break. The number of condomless receptive anal intercourse partners was stable over time. Sexually transmitted infections (STI) were common but chlamydia declined over the study period. The 12-month incidence of diagnosed infection was 8.7% for syphilis, 36.0% for gonorrhoea, 46.0% for chlamydia, 44.7% for rectal STI and 64.0% for any STI.