A detailed analysis is provided of the Stanford Medical Youth Science Program (SMYSP), a biomedical pipeline programme that seeks to diversify the health professions by providing academic enrichment in the medical sciences and college admissions support to very low-income high school students. Since its inception in 1988, 405 students have completed SMYSP and 96% have been observed for up to 18 years. The majority are from under-represented minority groups, many with poor academic preparation. This report highlights the extremely successful components of this programme that have enabled the students to succeed and prepared them for medical and other careers.