To examine time trends and ethnic disparities in hepatocellular carcinoma (HCC) incidence, risk factors, comorbidity and treatment pathways, data from Jan 1 2006 to Dec 31 2008 were analysed and identified 97 Māori and 92 non-Māori patients with HCC for hospital note review. Time trends were determined from NZ population (1981–2004) cohorts linked probabilistically to cancer registry records. The incidence of liver cancer was higher in Māori across all time periods. In comparison with non-Māori, Māori males had almost a 5-fold higher rate of liver cancer (RR 4.79; 95% CI 4.14-5.54), while Māori females had a 3-fold higher rate (RR 3.02; 95% CI 2.33-3.92). Tumour characteristics and treatment of Māori and non-Māori patients with HCC did not differ. Hypertension was more common in Māori (51% vs 25%) while cirrhosis was more common in non-Māori (62% vs 41%). Hepatitis B prevalence in Māori patients was double that of non-Māori (56% vs 27%), while the HR for cancer-specific death was 1.36 (95% CI 0.96-1.92) for Māori versus non-Māori.