These US-based researchers discuss their proposed new generation of health disparities research that is grounded in public health critical race praxis and employs comprehensive interventions to address race, racism, and structural inequalities and advancing evaluation methods, as a means of achieving health equity. The researchers examined a conceptual framework of three generations of health disparities research to understand data trends, factors driving disparities, and solutions for closing the gap. Their research model addresses the researcher’s own biases as part of the research process