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A retrospective cohort study of patients with stomach and liver cancers: the impact of comorbidity and ethnicity on cancer care and outcomes

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Summary:

These researchers examined the inter-relationships between comorbidity, receipt of treatment, ethnicity and cancer survival among a cohort of patients with liver and stomach cancers in New Zealand. New Zealand Cancer Registry data identified 269 Māori patients diagnosed with stomach and liver cancers, who were compared with a randomly selected group of 255 non-Māori patients. By 2 years post-diagnosis, over 70% of patients had died. As comorbidity burden increased among those with Stage I–III disease, it was increasingly less likely that the patient would receive curative surgery (e.g., C3 Index score 6 vs 0, adjusted odds ratio [OR] 0.32; 95% CI, 0.13 to 0.78) and the risk of mortality increased (e.g., C3 Index score 6 vs 0, adjusted all-cause hazards ratio [HR] 1.44; 95% CI, 0.93 to 2.23). Receipt of curative surgery reduced this excess mortality, in some cases substantially; the extent to which this occurred varied by level of comorbidity. Māori patients had somewhat higher levels of comorbidity (34% in highest comorbidity category compared with 23% for non-Māori) and poorer survival that could not be explained by age, sex, site, stage, comorbidity or receipt of curative surgery (adjusted cancer-specific HR 1.36; 95% CI, 0.97 to 1.90; adjusted all-cause HR 1.33; 95% CI, 0.97 to 1.82). Access to healthcare factors accounted for 25–36% of this survival difference.

Comment:
A very comprehensive review of differences in outcomes for common cancers for Māori. I would encourage clinicians to use a similar approach in clinical audits
Reference: BMC Cancer. 2014;14:821
Independent commentary by Dr. Matire Hardwood

Dr Matire Harwood (Ngapuhi) has worked in Hauora Māori, primary health and rehabilitation settings as clinician and researcher since graduating from Auckland Medical School in 1994. She also holds positions on a number of boards, committees and advisory groups including the Health Research Council. Matire lives in Auckland with her whānau including partner Haunui and two young children Te Rangiura and Waimarie.

Research Review publications are intended for New Zealand health professionals.

Disclaimer: This publication is not intended as a replacement for regular medical education but to assist in the process. The reviews are a summarised interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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