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Considerations for study design and analysis for ethically and culturally safe DNA methylation research in Aotearoa New Zealand

Making Education Easy

From Māori Health Review Issue 120
Authors:
  • Rolleston A et al.
Summary:

The adoption of ethical, culturally attuned research frameworks in epigenetics to support Māori health advancement is promoted in an analysis of the Multi-Ethnic New Zealand Study of Acute Coronary Syndromes. The analysis followed Te Tiriti o Waitangi principles and used kaupapa Māori methodologies, emphasising equity, social accountability, and indigenous data sovereignty. As an exemplar, the analysis identified the potential of DNA methylation markers, such as cg05575921 in AHRR for smoking exposure assessment, as well as the risks, including genetic confounding, population-specific variation, and the potential for individual and transgenerational stigma. Multi-ethnic validation of DNA methylation markers is needed to prevent exacerbation of health inequities, the authors stated.

Comment:
While genetic research and testing can be sensitive terrain for Māori, there may be substantial benefits for Māori health if it is conducted carefully, transparently and in partnership. So, it’s essential that we have open conversations with researchers about how such research can advance equity rather than reinforce harm.
Reference: SSM Popul Health. 2025;33:101889.
Abstract
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Independent commentary by Dr. Matire Hardwood

Dr Matire Harwood (Ngapuhi) has worked in Hauora Māori, primary health and rehabilitation settings as clinician and researcher since graduating from Auckland Medical School in 1994. She also holds positions on a number of boards, committees and advisory groups including the Health Research Council. Matire lives in Auckland with her whānau including partner Haunui and two young children Te Rangiura and Waimarie.

Research Review publications are intended for New Zealand health professionals.

Disclaimer: This publication is not intended as a replacement for regular medical education but to assist in the process. The reviews are a summarised interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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