This study demonstrated how collaboration with community and the incorporation of Indigenous worldviews can be applied to molecular biology studies in a practical and culturally responsive manner, ensuring fair and equitable representation of Indigenous peoples in modern scientific data. Strategies were developed for the use of Māori participant samples for live tissue and sequencing studies, using key pillars from currently available Indigenous bioethics frameworks. Strategies were based on extensive collaborations with the local Māori community, scientific leaders, and clinical experts, as well as researchers at the Broad Institute of Massachusetts Institute of Technology and Harvard University in the US. Discussions covered issues surrounding the use of live tissue, genomic data, sending samples overseas and Indigenous data sovereignty.