An analysis of skin swab culture results identified groups that are more likely to test positive for Streptococcal pyogenes (S. pyogenes). Over one-quarter of Auckland’s population were tested for suspected skin infections in primary care over the period 2010 to 2020. S. pyogenes infection rates were 3.1 (95% confidence interval [CI] 3.1-3.2) times higher for individuals aged <10 vs ≥10 years, 4.7 (95% CI 4.6-4.8) times higher for Māori or Pacific vs European/Other individuals, and 2.1 (95% CI 1.9-2.3) times higher for individuals in lower vs higher socioeconomic areas. Staphylococcus aureus (S. aureus) infection was found across all demographic groups. Individuals who tested positive for S. aureus were 2.1 (95% CI 1.9-2.3) times as likely to also test positive for S. pyogenes.