This study explored the role of cultural factors on the work experience of Māori scientists. A Kaupapa Māori research approach was used, and involved interviews with and observations of Māori scientists, as well as online data gathering and analysis of job descriptions/contracts for scientist roles explicitly targeting Māori. Cultural themes identified included whakawhanaungatanga (relationship management), kawenga (responsibilities), taumaha (workload), āheinga tangata (human capacity), tikanga (correct practice), hauora (well-being), and umanga takaware (career disruption). The study found that Māori scientists feel they operate across two worlds and thus operate with aronga takirua (cultural double-shift). A theoretical model was presented for understanding the drivers and consequences of this cultural double-shift. Overall, there was limited employer support for adequate engagement in cultural roles.