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Hyperglycaemia and ethnicity in patients with acute coronary syndromes

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Authors:
Summary:

This New Zealand based, retrospective analysis (n = 4,408) assessed the predictive value of admission blood glucose (ABG) and ethnicity with respect to the mortality of patients with acute coronary syndromes (ACS). Those patients presenting with acute ST elevation myocardial infarction (STEMI) were more likely to suffer early mortality. Poor patient outcome was also associated with a diagnosis of diabetes mellitus (DM) or elevated ABG (in the absence of DM). Mäori were more likely than European to have diabetes (33% vs 17.5%, p < 0.001). Those patients who made up the highest glucose category were older, more likely to be Mäori, had a higher prevalence of diabetes and longer hospital stays than those patients with lower blood glucose. Mortality risk factors included gender, age, ethnicity, diabetes, glucose and STEMI. The risk of mortality increased by 4.3% with each mmol/l increase in glucose. Following adjustments for age and gender, Mäori ACS patients had a much higher mortality than Europeans (RR 2.12; p < 0.00001), regardless of ACS type, with raised ABG being an indicator of this increased risk.

Comment:
The authors also found that the people admitted to hospital with ACS during the time period did not receive evidence based interventions. Angiography and revascularization procedures were performed less frequently in patients with DM than patients without DM. Intensive glycaemic management of ACS in people with raised blood glucose (shown to be effective in the DIGAMI study 1994) was attempted in only 10% of the sample. After adjusting for other covariates (age, gender, diabetes, diagnosis) Mäori had higher mortality from ACS than NZ Europeans. As the authors state, “High risk patient groups should be targeted aggressively with evidence-based care to reduce cardiovascular morbidity and mortality”.
Reference: Diabetes, Obesity and Metabolism. 2007; 9(1):121-126
Independent commentary by Dr. Matire Hardwood

Dr Matire Harwood (Ngapuhi) has worked in Hauora Māori, primary health and rehabilitation settings as clinician and researcher since graduating from Auckland Medical School in 1994. She also holds positions on a number of boards, committees and advisory groups including the Health Research Council. Matire lives in Auckland with her whānau including partner Haunui and two young children Te Rangiura and Waimarie.

Research Review publications are intended for New Zealand health professionals.

Disclaimer: This publication is not intended as a replacement for regular medical education but to assist in the process. The reviews are a summarised interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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