Modest weight loss or no weight gain after several years may reduce progression to diabetes and improve glycaemic control in Māori and Pasifika adults with diabetes, according to a systematic review of 21 obesity intervention studies. Studies chosen for inclusion were heterogenous, with most graded as low quality. A total of 18 studies were eligible for quantitative analysis and five for qualitative analysis. Small but statistically significant improvements in weight and body mass index were reported in some studies. Social connection, sustainable lifestyle changes, culturally-centred interventions and incentives including money and enjoyment were key enablers. Barriers included difficulty in maintaining adherence with a programme due to factors such as lack of social support and malfunctioning or lost equipment. The study authors recommend urgent implementation of Māori and Pasifika-led weight loss programmes that promote sustainable lifestyle changes delivered in culturally and socially appropriate contexts.