Increased participation in lung cancer screening among Indigenous peoples requires leveraging of positive experiences and addressing barriers with culturally tailored education and strategic resource allocation, according to a systematic review of 19 studies. Studies were conducted in the US (n = 15), New Zealand (n = 3) and Canada (n = 1), and included a total of 23,715 Indigenous participants. New Zealand studies found that lung cancer screening is cost effective for Māori. Facilitators of lung cancer screening included positive views of the programme and trust in Indigenous-centred care/providers, family and community support, transportation or f lexible scheduling, culturally competent navigators and detailed health education. Barriers included limited knowledge about lung cancer screening/eligibility criteria, fear of the screening process or cancer diagnosis, mistrust or negative experiences in healthcare, cost and time constraints, limited transportation/resources and non-inclusive eligibility criteria.