These researchers discuss the exposure and enrichment activities provided by the Pipeline to Success programme run by the Health Careers Opportunities Program (HCOP) at Creighton University in the USA for participants beginning in middle school and continuing through a one-year postbaccalaureate component. These activities are designed to ensure that these students are knowledgeable about health professional careers and competitive in applying for these training programmes. Analyses of the programmes’ outcomes have shown that the middle-school participants demonstrate a different pattern of influence from the other programme components. As participants progressed through the Pipeline to Success HCOP at Creighton University, the programme resources impacted their desire to pursue health professional careers in addition to positively preparing them for health professional training programmes.