This report presents an analysis of data from the National Health and Nutrition Examination Survey III (n=19,275) for adults aged 17–90 years, in an investigation into how multiple persistent infections cluster within individuals and how this clustering varies by socioeconomic position and race/ethnicity in U.S. adults. A positive correlation was observed for seroprevalence of individual persistent infections, suggesting common factors related to exposure or susceptibility. In all multiple indicator multiple cause models, strong and significant independent predictors of infection burden in U.S. adults included education, income, and race/ethnicity.