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The efficacy of bupropion in the Mäori population

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From Māori Health Review Issue 2
Authors:
  • Holt S et al
Summary:

Around 50% of adult Mäori in New Zealand are smokers, as compared to around 20% of European New Zealanders. This randomised, placebo-controlled trial assessed the efficacy of bupropion as an intervention for smoking cessation in 134 Mäori smokers (> 10 cigarettes/day) aged 16-70 years. Continued abstinence from smoking at 3 and 12 months were the primary outcome measures. At 3 months, continued abstinence was higher with bupropion (44.3%) than placebo (17.4%), RR 2.54 (95% CI 1.30-5.00). At 12 months abstinence rates were 21.6 and 10.9% for the bupropion and placebo groups respectively, RR 1.99 (95% CI 0.79 to 5.00). In conclusion, the authors suggest that bupropion is an effective treatment for smoking cessation in the indigenous Mäori population in New Zealand.

Comment:
The motivation for this study came about after a conversation with Tariana Turia, the Assoc Minister for Health at the time. She sought evidence that bupropion was an effective treatment for smoking cessation in Mäori. What followed was this study, the first RCT with Mäori only participants. Despite evidence that bupropion is effective in helping Mäori to quit smoking it is not subsidised. The researchers, participants and those working in Auahi kore programmes are understandably disappointed that a significant cost barrier to an effective treatment exists.
Reference: Thorax. 2005; 60(2):120-3
Abstract
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Independent commentary by Dr. Matire Hardwood

Dr Matire Harwood (Ngapuhi) has worked in Hauora Māori, primary health and rehabilitation settings as clinician and researcher since graduating from Auckland Medical School in 1994. She also holds positions on a number of boards, committees and advisory groups including the Health Research Council. Matire lives in Auckland with her whānau including partner Haunui and two young children Te Rangiura and Waimarie.

Research Review publications are intended for New Zealand health professionals.

Disclaimer: This publication is not intended as a replacement for regular medical education but to assist in the process. The reviews are a summarised interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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