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The prescribing of cardioprotective medications and the impact on survival for patients with peripheral artery disease that undergo intervention

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Authors:
Summary:

A study of cardioprotective medication prescribing in patients with peripheral artery disease (PAD) has highlighted areas of deficiency, namely for women and Māori men. The study assessed 2547 patients who had undergone PAD-related percutaneous and surgical intervention between 2010 and 2021 in the Midland region of New Zealand. Overall, 80.7% of patients received a prescription for antihypertensive medication, 77.4% for lipid-lowering medication and 89.9% for antithrombotic medication. Patients with concomitant ischaemic heart disease were more likely to be prescribed cardioprotective medication. Women were less likely to be prescribed lipid-lowering medication than men, while Māori men were less likely to be prescribed antiplatelet medication compared with non-Māori men. Lipid-lowering and antiplatelet medication showed a survival advantage on univariate analysis, while antihypertensive and anticoagulant medication did not. Best medical therapy was associated with better survival after adjustment for age, sex, end stage renal failure and presence of chronic limb-threatening ischaemia (hazard ratio 0.88, 95% CI 0.79-0.98).

Comment:
So best practice medical treatment was associated with better survival, yet was not prescribed for Māori men over the last decade.
Reference: ANZ J Surg. 2023;93(10): 2376-2381.
Independent commentary by Dr. Matire Hardwood

Dr Matire Harwood (Ngapuhi) has worked in Hauora Māori, primary health and rehabilitation settings as clinician and researcher since graduating from Auckland Medical School in 1994. She also holds positions on a number of boards, committees and advisory groups including the Health Research Council. Matire lives in Auckland with her whānau including partner Haunui and two young children Te Rangiura and Waimarie.

Research Review publications are intended for New Zealand health professionals.

Disclaimer: This publication is not intended as a replacement for regular medical education but to assist in the process. The reviews are a summarised interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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