A study integrating retrospective and prospective data analyses has found that office based transperineal prostate biopsy is cost-effective, environmentally responsible, and offers socially equitable health care delivery. The study assessed changes in clinical workflows, financial savings, environmental impacts, and accessibility to care. Transitioning transperineal prostate biopsy to an office-based setting resulted in annual cost reductions of NZD 302,000, increased procedural capacity, and eliminated hospital admissions associated with transrectal ultrasound-guided-related sepsis. Greenhouse gas emissions were reduced, patient comfort was improved through fewer biopsy cores, health care worker burden was reduced, and access for Māori populations was improved via proposed mobile biopsy units.