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Warrior genes and risk-taking science

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Authors:
Summary:

In this article, the authors summarise their concerns with regard to the veracity and ethics of the “warrior gene” line of research. They raise concerns with regard to the informed consent process. In line with ethical principals of research, all participants should have been advised that the research included the exploration of hypotheses linking the “warrior gene” with violent and antisocial behaviour, and that results may be extrapolated from the research participants to the larger Mäori population despite the lack of evidence for association between the two. The authors ask questions about the scientific validity of an approach which has extrapolated from a small, likely non-random sample of Mäori males to not only the entire contemporary male Mäori population, but also to past generations. They also point to a lack of any association between genotype alone and anti-social behaviour from previous research and the risks of making a claim of causality on the evidence of association alone. Finally, the authors highlight the issue of skewed reporting and hype by the media, and comment that; “In such highly charged social and political settings, the scientist has a particular responsibility for the way in which findings are disseminated and for ensuring a clear public understanding of the limitations of the work to date.”

Comment:
Dr Rod Lea claimed in August 2006 that there is a genetic explanation for negative social and health statistics for Mäori. Dubbed the warrior gene, Dr Lea stated that the low-activity MAO-A genetic variant “goes a long way to explaining some of the problems Mäori have…they are going to be more aggressive and violent and more likely to get involved in risk-taking behaviour like gambling”. Unfortunately, information about the research came mainly via the media and the reports were sensationalised, simplified and from the perspective of Dr Lea and his team. The media were quick to point to Mäori and our genes as reasons to explain negative statistics. Not only were the wider, external issues ignored but scientists, ethicists and Mäori were not given the opportunity to voice their concerns about the study. Thankfully, we have now been provided with expert opinions around the science and ethics of Dr Lea’s work in the latest NZMJ. Dr Merriman and Dr Cameron question the scientific validity of Lea’s genetic studies and Professor Crampton and Dr Parkin raise important ethical concerns. If you are considering large scale genetic research in your whanau, hapu or iwi, it would be useful to read the articles in their entirety. Aroha Mead and Moana Jackson have also critiqued genetic research undertaken by Dr Lea and others using a Kaupapa Mäori epistemology. Their presentations were recorded at HRC’s Hui Whakapiripi and Pridoc in 2006. Some Iwi (Ngai Tahu for example) already have guidelines in place for DNA research and it may be useful to consider the development of guidelines or recommendations prior to participation in research in which DNA samples are taken.
Reference: JNZMA. 2007; 120(1250)
Independent commentary by Dr. Matire Hardwood

Dr Matire Harwood (Ngapuhi) has worked in Hauora Māori, primary health and rehabilitation settings as clinician and researcher since graduating from Auckland Medical School in 1994. She also holds positions on a number of boards, committees and advisory groups including the Health Research Council. Matire lives in Auckland with her whānau including partner Haunui and two young children Te Rangiura and Waimarie.

Research Review publications are intended for New Zealand health professionals.

Disclaimer: This publication is not intended as a replacement for regular medical education but to assist in the process. The reviews are a summarised interpretation of the published study and reflect the opinion of the writer rather than those of the research group or scientific journal. It is suggested readers review the full trial data before forming a final conclusion on its merits.

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