Expanding the prescriber cohort for isotretinoin in New Zealand has resulted in a substantial increase in prescriptions for acne, and partially reduced ethnic disparities, according to evaluation of national dispensing data from 2008 to 2023. Almost 100% (26,897) of isotretinoin prescriptions in 2008 were written by a dermatologist, while in 2023, 79% (39,432) were written by primary care clinicians. The number of prescriptions per year increased by 87% from 2008 to 2023, from 26,897 to 50,613. Among Māori, isotretinoin prescriptions increased from 1750 in 2008 to 4374 in 2023, and similar increases were noted for other ethnic minorities.