Prospective population-based study on the burden of disease from poststreptococcal glomerulonephritis of hospitalised children in New Zealand: epidemiology, clinical features and complications
Results are reported from this nationwide 24-month study conducted between 2007 and 2009 by the New Zealand Paediatric Surveillance Unit in order to define epidemiology and clinical features of acute post-streptococcal glomerulonephritis (APSGN) in children aged 0–14 years hospitalised with the illness. The study involved 215 paediatricians who reported 176 new hospitalised cases fulfilling a case definition of definite (haematuria with low C3 and high streptococcal titres or biopsy-proven APSGN; n=138) or probable (haematuria with low C3 or high streptococcal titres; n=38). Of all cases, 63% were residing in the Auckland metropolitan region and 67% were in the most deprived quintile. The annual incidence was 9.7/100,000 and overrepresented by Pacific and Māori children (45.5 and 15.7) compared with 2.6/100,000 European/other and 2.1/100,000 Asian. The highest annual incidence was recorded in the South Auckland Metropolitan region (31/100 000), versus 14.9 in Central Auckland, 5.9 in the West/North Auckland metropolitan region and 5.5 for the remainder of New Zealand. The highest age-specific incidence was among children aged 5–9 years (15.1/100,000). Reduced serum complement C3, gross haematuria, hypertension, impairment of renal function and heavy proteinuria were found in 93%, 87%, 72%, 67% and 44% of patients, respectively. Severe hypertension was closely associated with either symptoms of an acute encephalopathy or congestive heart failure.
Of concern, Māori children showed a significant reduction in admission numbers in Auckland in the 1980-90s; however, rates in Auckland have risen again, and nationally the rate in Māori is six times higher than in European/other children. As the authors point out, other potentially avoidable infectious diseases such as cellulitis, rheumatic fever and respiratory illness are also more frequent among Māori and Pacifica children. This is due to multiple, but potentially reversible, factors (such as poverty, poor education, crowded housing and access to health care).
Reference: J Paediatr Child Health 2013;49(10):850-5