Ethnicity accounted for a 3-fold variation in one-year mortality after first myocardial infarction according to results of a registry study. A total of 17,404 patients hospitalised with their first myocardial infarction between 2014 and 2017, and who underwent coronary angiography, were identified from the All New Zealand Acute Coronary Syndrome Quality Improvement (ANZACS-QI) registry. Patients’ ethnicity was reported as European/other (76%), Māori (11.5%), Pacific (5.1%), Indian (4.3%), and Other Asian (2.9%). The hospital admission rate for first myocardial infarction before age 60 years was 29% for patients of European/other ethnicity and 55% for patients of Māori, Pacific and Indian ethnicity. Māori and Pacific patients were more likely to present with heart failure and advanced coronary disease. Māori patients had a significantly higher all-cause mortality at 1 year compared with European/other patients (HR 2.55; 95% CI 2.12–3.07).