A multi-method study has highlighted the important role the health sector plays in redressing the power imbalance between harmful commodity industries and communities. The study incorporated literature reviews of commercial determinants of health (CDoH) strategies and ways in which organisations can respond; policy document review; and 12 qualitative, semistructured, key informant interviews. A theoretical framework was developed summarising CDoH and potential responses, which included raising awareness about CDoH; strengthening policies related to interactions with corporations, in particular considering alignment of values; supporting community actions; and advocating for legislative changes to restrict the power of harmful industries.