Uptake of haemodiafiltration increased over time in a cohort study of 27,433 patients commencing haemodialysis on the Australian and New Zealand Dialysis and Transplant Registry. Uptake of haemodiafitration was more rapid in New Zealand than Australia with 19.1% and 14.4% of patients commencing haemodiafiltration in each country, respectively. In New Zealand, Māori and Pasifika (OR 1.32; 95% CI 1.05–1.66) or Asians (OR 1.75; 95% CI 1.15–2.68) were more likely to use haemodiafiltration than Caucasians. Centre-related factors accounted for 48% variability in uptake of haemodiafiltration in New Zealand.